李长勇 副教授

职称职务：副教授，硕士生导师，系副主任

学科专业：生理学

研究方向：1. 急/慢性肝损伤的细胞与分子机制；2. 干细胞免疫调控与治疗

实验室位置：基础医学院11号楼102

Email：lichangyong@whu.edu.cn

学习经历

2006.9-2009.7  首都医科大学 细胞生物学专业 博士学位

2015.5-2016.5/2018.5-2019.5 美国加州大学洛杉矶分校（UCLA）博士后

主要工作经历与任职

2011.10-今 武汉大学 基础医学院生理学系  讲师、副教授

2009.8-2011.9 首都医科大学 基础医学院细胞生物学系  讲师

目前主要科学研究领域和兴趣

致力于各种急性和慢性肝损伤包括药物性肝损伤、肝脏缺血再灌注损伤、代谢功能障碍性脂肪性肝病、以及肝纤维化/肝硬化的发病机制研究，利用多组学以及现代细胞与分子生物学技术和模式动物，从分子、细胞、组织、器官及整体水平，深入系统解析肝损伤过程中的信号调控网络，以及间充质干细胞的免疫调控与治疗机理，为临床各种肝病治疗提供新的药物靶标。

主要学术兼职

湖北省生理学会常务理事；教育部学位中心学位论文评审专家；北京市自然科学基金评审专家、广东省自然科学基金评审专家；《Signal Transduct Target Ther》、《Kidney Int》、《Aging Cell》、《Stem Cell Res Ther》、《FASEB J》等SCI期刊审稿专家。

教学情况

主讲临床医学5、5+3、8年制和口腔、护理、基础医学等专业《生理学》、《组织与功能》、《机能实验学》、《早期接触临床》和留学生《Physiology》等课程。

获奖及荣誉

武汉大学本科优秀教学业绩奖（2021）

第七届全国基础医学创新论坛中南赛区三等奖（指导教师2021）

武汉大学教学成果二等奖（2021）

武汉大学首届板书技能微赛三等奖（2018）

首届全国高校生理学微课教学大赛二等奖（2017）

入选武汉大学珞珈青年学者（2012）

入选北京市50篇优博论文（2010）

代表性论文

1. Changyong Li, Yuting Jin, Song Wei, Yishuang Sun, Longfeng Jiang, Qiang Zhu, Douglas G Farmer, Ronald W Busuttil, Jerzy W Kupiec-Weglinski, Bibo Ke. Hippo Signaling Controls NLR Family Pyrin Domain Containing 3 Activation and Governs Immunoregulation of Mesenchymal Stem Cells in Mouse Liver Injury. Hepatology. 2019;70(5):1714-1731.（中科院一区Top）

2. Changyong Li, Mingwei Sheng, Yuanbang Lin, Dongwei Xu, Yizhu Tian, Yongqiang Zhan, Longfeng Jiang, Ana J Coito, Ronald W Busuttil, Douglas G Farmer, Jerzy W Kupiec-Weglinski, Bibo Ke. Functional crosstalk between myeloid Foxo1-β-catenin axis and Hedgehog/Gli1 signaling in oxidative stress response. Cell Death Differ. 2021;28(5):1705-1719.（中科院一区Top）

3. Yuting Jin^#, Changyong Li^#, Dongwei Xu, Jianjun Zhu, Song Wei, Andrew Zhong, Mingwei Sheng, Sergio Duarte, Ana J Coito, Ronald W Busuttil, Qiang Xia, Jerzy W Kupiec-Weglinski, Bibo Ke. Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury. Cell Mol Immunol. 2020;17(12):1245-1256. （中科院一区Top）

4. Ruobin Zong, Yujie Liu, Mengya Zhang, Buwei Liu, Wei Zhang, Hankun Hu*, Changyong Li*. β-Catenin disruption decreases macrophage exosomal α-SNAP and impedes Treg differentiation in acute liver injury. JCI Insight. 2025;10(1):e182515.（中科院一区Top）

5. Yan Yang, Ming Ni, Ruobin Zong, Mengxue Yu, Yishuang Sun, Jiahui Li, Pu Chen*, Changyong Li*. Targeting Notch1-YAP Circuit Reprograms Macrophage Polarization and Alleviates Acute Liver Injury in Mice. Cell Mol Gastroenterol Hepatol. 2023;15(5):1085-1104.（中科院一区Top）

6. Mengya Zhang, Kun Li, Xiaoxing Huang, Dongqin Xu, Ruobin Zong, Qintong Hu, Xiaoyu Dong, Qinyong Zhang, Chaochen Jiang, Yue Ge, Changyong Li*, Jie Ping*. Macrophage Notch1 signaling modulates regulatory T cells via the TGFB axis in early MASLD. JHEP Rep. 2025;7(1):101242.（中科院一区Top）

7. Ruobin Zong, Yan Zheng, Yufei Yan, Wenao Sun, Liangyi Kong, Yating Huang, Yujie Liu, Chaochen Jiang, Jie Ping, Changyong Li*. Mesenchymal stem cells-derived exosomes alleviate liver fibrosis by targeting Hedgehog/SMO signaling. Hepatol Int. 2024;18(6):1781-1791.（中科院一区Top）

8. Changyong Li, Zheng S, You H, Liu X, Lin M, Yang L, Li L*. Sphingosine 1-phosphate (S1P)/S1P receptors is involved in human liver fibrosis by action on hepatic myofibroblasts motility. J Hepatol 2011; 54(6):1205-1213. (中科院一区Top)

9. Changyong Li, Kong Y, Wang H, Wang S, Yu H, Liu X, Yang L, Jiang X, Li L, Li L*. Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis. J Hepatol 2009; 50(6):1174-1183. (中科院一区Top)

10. Ke Zhang, Shuo Zheng, Jiasheng Wu, Jing He, Yu Ouyang, Chunchun Ao, Ruibo Lang, Yijia Jiang, Yifan Yang, Huan Xiao, Yu Li, Mao Li, Huiming Wang, Changyong Li*, Dongcheng Wu*. Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate renal fibrosis in diabetic nephropathy by targeting Hedgehog/SMO signaling. FASEB J. 2024;38(7):e23599.（中科院二区）

11. Mengxue Yu, Min Zhou, Jiahui Li, Ruobin Zong, Yufei Yan, Liangyi Kong, Qiang Zhu*, Changyong Li*. Notch-activated mesenchymal stromal/stem cells enhance the protective effect against acetaminophen-induced acute liver injury by activating AMPK/SIRT1 pathway. Stem Cell Res Ther. 2022;13(1):318.（中科院二区）

12. Yaqi Zhang, Xi Le, Shuo Zheng, Ke Zhang, Jing He, Mengting Liu, Chengshu Tu, Wei Rao, Hongyuan Du, Yu Ouyang, Changyong Li*, Dongcheng Wu*. MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization. Stem Cell Res Ther. 2022;13(1):171.（中科院二区）

13. Jing He, Chunchun Ao, Mao Li, Taoran Deng, Shuo Zheng, Ke Zhang, Chengshu Tu, Yu Ouyang, Ruibo Lang, Yijia Jiang, Yifan Yang, Changyong Li*, Dongcheng Wu*. Clusterin-carrying extracellular vesicles derived from human umbilical cord mesenchymal stem cells restore the ovarian function of premature ovarian failure mice through activating the PI3K/AKT pathway. Stem Cell Res Ther. 2024;15(1):300.（中科院二区）

14. E Xiang, Bing Han, Quan Zhang, Wei Rao, Zhangfan Wang, Cheng Chang, Yaqi Zhang, Chengshu Tu, Changyong Li*, Dongcheng Wu*. Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Res Ther. 2020;11(1):336.（中科院二区）